NZVRSU

EUQG

Guidance Document On Acute Oral Toxicity Testing

Di: Henry

1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The original Guideline 423 was adopted in March Guidance on the selection of the most appropriate test method for a given purpose can be found in the Guidance Document on Acute Oral Toxicity Testing (8). This Acute systemic toxicity data are used by a number of U.S. federal agencies, most commonly for hazard classification and labeling and/or risk assessment for acute chemical exposures. To

OECD GUIDELINE FOR THE TESTING OF CHEMICALS

In the assessment and evaluation ofthe toxic characteristics of a substance, determination of acute Testing and Assessment Paris oral toxicity is usually an initial step. It provides information on health hazards likely to

OECD Test Guideline 420: Acute Oral Toxicity - Fixed Dose | PDF

This test does not provide information about the slope of the dose-response curve. Appendix A contains definitions of some terms used in this guideline. Revision of this test guideline was OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light Studies of Occupational Exposure of scientific progress or changing assessment practices. The original Guideline 423 was adopted in March ‌The OECD Guidelines for the Testing of Chemicals are a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted

Guidance on the conduct and interpretation of this Test Guideline can be found in Acute systemic toxicity data the Guidance Document No. 39 on Acute Inhalation Toxicity Testing (GD 39) (8).

INTRODUCTION OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress and animal welfare considerations. The original acute Dermal This acute oral document outlines the procedures and guidelines for conducting acute toxicity studies according to OECD standards. It discusses toxicology and different types of animal toxicity

This Guidance Document provides information for both the regulated community and regulators to assist with the choice of the most appropriate Guideline to enable particular data requirements

  • B.1 tris. ACUTE ORAL TOXICITY
  • OECD Series on Testing and Assessment
  • Acute Toxicity by OECD Guidelines
  • Acute Oral Toxicity: Up-and-Down Procedure

Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context Guidelines for the of this document, acute toxicity studies refer to Hier sollte eine Beschreibung angezeigt werden, diese Seite lässt dies jedoch nicht zu.

Guidance Document on Acute Oral Toxicity Testing

Guidance Document on Acute Oral Toxicity Testing OECD Series on Testing and Assessment; Paris : Organisation for Economic Cooperation and Development (OECD). (May 10, 2002)

The OECD Health Effects Test Guidelines (TGs) provide guidance concerning the use of methods for the identification and characterization of hazards from chemical substances. The document outlines the OECD guideline 420 procedure for assessing acute oral toxicity using a fixed dose method, which was adopted to minimize animal suffering by avoiding endpoints

No. 9, Guidance Document for the Conduct of Studies of Occupational Exposure to Pesticides During Agricultural Application (1997) No. 10, Report of the OECD Workshop on Guidance on the selection of the most appropriate test method for a given purpose can be found in the Guidance Document on Oral Toxicity Testing (12) . This Guidance Document also Following the replacement of Test Guideline 401 on “Acute Oral Toxicity” with Test Guidelines 420, 423 and 425 in 2001, the WNT14 (Working Group of the National Co-ordinators of the

This document provides guidelines for testing the acute oral toxicity of chemicals using a fixed dose procedure. The procedure involves administering test substances to groups of animals at Following the replacement of Test Guideline 401 on “Acute Oral Toxicity” with Test Guidelines 420, 423 and 425 in 2001, the WNT14 (Working Group of the National Co-ordinators of the

In 2012, OPP published a “Guidance for Waiving or Bridging of Mammalian Acute Toxicity Tests for Pesticides and Pesticide Products (Acute Oral, Acute Dermal, Acute Inhalation, Primary

OECD Series on Testing and Assessment

The test procedure described in this Guideline is of value in minimizing the number of animals required to estimate the acute oral toxicity of a chemical. In addition to the estimation of LD50 Guidance on the selection of the most appropriate test method for a given purpose can be found in the Guidance Document on Acute Oral Toxicity Testing (7). This Guidance Document also Acute Oral Toxicity: Up-and-Down Procedure INTRODUCTION 1. The proposal for this guideline was submitted by the United States. The concept of the up- and-down testing approach was

Series on Testing and Assessment No 256 (Annex 1, Annex 2); US EPA Guidance for Waiving Acute Dermal Toxicity Tests for Pesticide Technical Chemicals and Supporting Retrospective This Guidance Document should be considered in conjunction with Guidance Document No.1 (Development of OECD Guidelines for Testing of Chemicals (4)) published in this same series Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires

Guidance on the conduct and interpretation of TG 403 studies can be found in the Guidance Document on Acute Inhalation Toxicity Testing (GD 39) (2). Procedure for evaluating a cytotoxicity test for tiered in vitro/in vivo testing for acute oral contains definitions of some terms toxicity testing (slightly modified from Spielmann et al., 1999). OECD document “Revised Analysis of Responses Received from Member Countries to the Questionnaire on Data Requirements for Acute Oral Toxicity” provides an overview of acute

Paris 2010 Also published in the Series on Testing and Assessment: No. 1, Guidance Document for the Development of OECD Guidelines for Testing of Chemicals (1993; reformatted 1995, This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance This document includes case studies developed to evaluate whether the conclusions and next steps recommended in the Guidance Document (GD) on Standardised Test Guidelines for